Our students are often involved in the creation of intellectual property and the dissemination of scientific findings. Below is the summary of journal articles, conference proceedings, and patent applications to which students contributed. This list does not include approximately 120 oral and poster presentations made by our students (as first authors) at professional meetings and conferences outside of Vanderbilt.

Journal Articles:


1.      Faley S, Seale K, Hughey J, Schaffer DK, VanCompernolle S, McKinney B, Baudenbacher F, Unutmaz D, Wikswo JP, Microfluidic Platform for Real-Time Signaling Analysis of Multiple Single T Cells in Parallel, Lab Chip, 8:1700-1712 (2008)

2.      Gorman BR, Wikswo JP, Characterization of Transport in Microfluidic Gradient Generators, Microfluid. Nanofluid., 4:273-285 (2008)

3.      Harris M, Kim E, Weidow B, Wikswo JP, Quaranta V, Migration of Isogenic Cell Lines Quantified by Dynamic Multivariate Analysis of Single-Cell Motility, Cell Adh. Migr., 2:127-136 (2008)

4.      Seale KT, Reiserer R, Markov D, Ges I, Wright C, Janetopoulos C, Wikswo JP, Mirrored Pyramidal Wells for Simultaneous Multiple Vantage Point Microscopy, J. Microsc., 232, Pt 1:1-6 (2008)

5.      Elzie CA, Colby J, Sammons MA, Janetopoulos C, Dynamic Localization of G Proteins in Dictyostelium Discoideum, J. Cell Sci., 2597-2603 (2009)

6.      Darby S, Moore M, Wikswo JP, Reiserer R, Friedlander T, Schaffer DK, Seale KT, A Metering Rotary Nanopump for Microfluidic Systems, Lab Chip, 10:3218-3226 (2010)

7.      Enders JR, Masasco CC, Kole A, Nguyen B, Sundarapandian S, Seale KT, Wikswo JP, McLean JA, Towards Monitoring Real-Time Cellular Response Using an Integrated Microfluidics-Matrix Assisted Laser Desorption Ionisation/Nanoelectrospray Ionisation-Ion Mobility-Mass Spectrometry Platform, IET Syst. Biol., 4:416-427 (2010)

8.      Markov DA, Manuel S, Shor L, Opalenik SR, Wikswo JP, Samson PC, Tape Underlayment Rotary-Node (TURN) Valves for Simple On-Chip Microfluidic Flow Control, Biomed. Microdevices, 12:135-144 (2010)

9.      Markov DA, Samson PC, Schaffer DK, Dhummakupt A, Wikswo JP, Shor LM, Window on a Microworld: Simple Microfluidic Systems for Studying Microbial Transport in Porous Media, J. Vis. Exp., 39:1741 (2010)

10.   Seale K, Faley S, Chamberlain J, Wikswo JP, Macro to Nano: A Simple Method for Transporting Cultured Cells from Milliliter Scale to Nanoliter Scale, Exp. Biol. Med., 235:777-783 (2010)

11.   Markov DA, Lu JP, Samson PC, Wikswo JP, McCawley LJ, Thick-Tissue Bioreactor as a Platform for Long-Term Organotypic Culture and Drug Delivery, Lab Chip, 12:4560-4568 (2012)

12.   Deng J, Dhummakupt A, Samson P, Wikswo JP, Shor LM, Dynamic Dosing Assay Relating Real-Time Respiration Responses of Staphylococcus aureus Biofilms to Changing Microbial Conditions, Anal. Chem., 85:5411-5419 (2013)

13.   Wikswo JP, Curtis E, Eagleton Z, Evans B, Kole A, Hofmeister L, Matloff W, Scaling and Systems Biology for Integrating Multiple Organs-on-a-Chip, Lab Chip, 13:3496-3511 (2013)

14.   Srinivasan K, Wright GA, Hames N, Housman M, Aufdeheide KJ, Janetopoulos C, Delineating the Core Regulatory Elements Critical for Directed Cell Migration by Examining Folic Acid-Mediated Responses, J. Cell Sci., 126(Pt.1):221-233 (2013)

15.   Markov DA, Lillie EM, Garbett SP, McCawley LJ, Variation in Diffusion of Gases Through PDMS Due to Plasma Surface Treatment and Storage Conditions, Biomed. Microdevices, 16:91-96 (2014)

16.   Yan Y, Jiang L, Aufderheide KJ, Wright GA, Terekhov A, Costa L, Qin K, McCleery WT, Fellenstein JJ, Ustione A, Robertson JB, Johnson CH, Piston DW, Hutson MS, Wikswo JP, Hofmeister W, Janetopoulos C, A Microfluidic-Enabled Mechanical Microcompressor for the Immobilization of Live Single- and Multi-Cellular Specimens, Microsc. Microanal., 20:141-151 (2014)

17.   Wu SH, Hernandez N, Bain E, Bulow C, Gamse, J “Mediator subunit 12 coordinates intrinsic and extrinsic control of epithalamic development,” Dev. Biol., 385(1): 13-22 (2014)

18.   Byrd TF, Hoang LT, Kim EG, Pfister ME, Werner EM, Arndt SE, Chamberlain JW, Hughey JJ, Nguyen BA, Schneibel EJ, Wertz LL, Whitfield JS, Wikswo JP, Seale KT, "The Microfluidic Multitrap Nanophysiometer for Hematologic Cancer Cell Characterization Reveals Temporal Sensitivity of the Calcein-AM Efflux Assay," Sci. Rep., 4:Article 5117 (2014)

19.   Hockemeyer K, Janetopoulos C, Terekhov A, Hofmeister W, Vilgelm A, Wikswo JP, Richmond A, "Engineered Three-Dimensional Microfluidic Device for Interrogating Cell-Cell Interactions in the Tumor Microenvironment," Biomicrofluidics, 8:044105-1-044105-12 (2014)

20.   Crowder SW, Balikov DA, Hwang Y, Sung HJ, "Cancer Stem Cells Under Hypoxia as a Chemoresistant Factor in Breast and Brain," Curr. Pathobiol. Rep., 2:33-40 (2014)

21.   Zachman AL, Hofmeister LH, Costa L, Boire TC, Hwang Y, Hofmeister WH, Sung HJ, "Femtosecond Laser-Patterned Nanopore Arrays for Surface-Mediated Peptide Treatment," Nanomedicine: NBM, 10:11-14 (2014)

22.   Stow SS, Onifer TM, Forsythe JG, Nefzger H, Kwiecien NW, May JC, McLean JA, Hercules DM, “Structural Characterization of Methylenedianiline Regioisomers by Ion Mobility-Mass Spectrometry, Tandem Mass Spectrometry, and Computational Strategies. 2. Electrospray Spectra of 3‐Ring and 4‐Ring Isomers,” Analytical Chemistry, 87:6288-6296 (2015)

23.   Forsythe JG, Stow SS, Nefzger H, Kwiecien NW, May JC, McLean JA, Hercules DM, Structural Characterization of Methylenedianiline Regioisomers by Ion Mobility-Mass Spectrometry, Tandem Mass Spectrometry, and Computational Strategies: I. Electrospray Spectra of 2‐Ring Isomers,” Analytical Chemistry, 86:4362-4370 (2014)

24.   Brown JA, Pensabene V, Markov DA, Allwardt V, Neely M, Diana Shi M, Britt CM, Hoilett OS, Yang Q, Brewer BM, Samson PC, McCawley LJ, May JM, Webb DJ, Li D, Bowman AB, Reiserer RS, and Wikswo JP, “Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor,” Biomicrofluidics, 9, 054124 (2015)

25.   Katsha A, Wang L, Arras J, Omar OM, Ecsedy JA, Belkhiri A, and El-Rifai W, “Activation of EIF4E by Aurora kinase A depicts a novel druggable axis in everolimus resistant cancer cells,” Clinical Cancer Research, 23(14): 3756-3768 (2017)

26.   Shilts J, Broadie K “Secreted Tissue Inhibitor of Matrix Metalloproteinase Restricts Trans-Synaptic Signaling to Coordinate Synaptogenesis,” Journal of Cell Science, 130: 2344-2358 (2017)

27.   Matta P, Sherrod SD, Marasco CC, Moore DJ, McLean JA and Weitkamp JH, “In Utero Exposure to Histological Chorioamnionitis Primes the Exometabolomic Profiles of Preterm CD4+ T Lymphocytes," The Jounal of Immunology, 199: 3074-3085 (2017)

28.   Cyr KJAlvaldi OM, Wikswo, JP "Circadian hormone control in human-on-a-chip: In vitro biology's ignored component?," Experimental Biology and Medicine, 242(17): 1714-1731 (2017)

29.   Joffe ME, Santiago CI, Engers JL, Lindsley CW, Conn PJ "Metabotropic glutamate receptor subtype 3 gates acute stress-induced dysregulation of amygdalo-cortical function," Molecular Psychiatry (2017)

30.   Curtisa C, Toghanib D, Wong B, Nance E “Colloidal Stability as a Determinant of Nanoparticle Behavior in the Brain,” Colloids and Surfaces B: Biointerfaces (2018)

31.   Faley SL, Neal EH, Wang JX, Bosworth AM, Weber CM, Balotin KM, Lippmann ES, Bellan LM “iPSC-Derived Brain Endothelium Exhibits Stable, Long-Term Barrier Function in Perfused Hydrogel Scaffolds,” Stem Cell Reports (2019)

32.   Joffe ME, Santiago CI, Stansley BJ, Maksymetz J, Gogliotti RG, Engers JL, Nicoletti F, Lindsley CW, Conn PJ “Mechanisms Underlying Prelimbic Prefrontal Cortex mGlu3/mGlu5-dependent Plasticity and Reversal Learning Deficits Following Acute Stress,” Neuropharmacology (2019)

33.   Dunham WC, Weinger MB, Slagle J, Shah AS, Absi TS, Shotwell MS, Beller M, Thomas E, Vnencak-Jones CL, Freundlich RE, Wanderer JP, Sandberg WS, Kertai MD “CYP2D6 genotype-guided metoprolol therapy in cardiac surgery patients: Rationale and design of the Pharmacogenetic-guided Metoprolol Management for Postoperative Atrial Fibrillation in Cardiac Surgery (PREEMPTIVE) Pilot study,” Journal of Cardiothoracic and Vascular Anesthesia (2019)

34.    Quah, K, Poorman, ME, Allen, SP, Grissom, WA “Simultaneous multislice MRI thermometry with a single coil using incoherent blipped‐controlled aliasing,” Magnetic Resonance in Medicine (2019).

Conference Proceedings, Application Notes, and Other Publications:


1.      Hughey J, Wikswo JP, Seale KT, Intra-Microfluidic Pinocytic Loading of Human T Cells, IEEE/NIH Life Science Systems and Applications Workshop (LISSA), pp. 132-135 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4344306/ (2007)

2.      Kim EGR, Sivasubramaniam P, Wikswo JP, Seale KT, Differential Optical Flow for Automated Cell Motility, MicroTAS Tech Digest 2008: Twelfth International Conference on Miniaturized Systems for Chemistry and Life Sciences, Locascio,LE, ed. Chemical and Biological Microsystems Society, San Diego, CA, October 12-16:1831-1833 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4038811/ (2008)

3.      Giron LC, Hoang L, Herrera-Flores A, Scherrer J, Seale K, Low Volume Bacterial Chemostat in Microfluidic Devices through the Use of Hexagonal Traps, Young Scientist, https://www.youngscientistjournal.org/wp-content/uploads/sites/16/2015/08/2012-05_article_giron.pdf(2012)

4.      Seale KT, Rogers M, Reiserer RS, Embossed Foil Microfluidics for the Classroom, ASEE Southeast Section Conference, http://se.asee.org/proceedings/ASEE2014/Papers2014/4/127.pdf (2014)

5.      Bowman A, Scherrer J, Reiserer R, Note: A Single-Chamber Tool for Plasma Activation and Surface Functionalization in Microfabrication, Rev. Sci. Instr. http://scitation.aip.org/content/aip/journal/rsi/86/6/10.1063/1.4922827 (2015)

Patents and Patent Applications:


1.      Helical Peristaltic Nanopump for BioMEMS Devices, Schaffer DK, Reiserer R, Darby S, Seale KT, Wikswo JP, US Patent Application Serial No. 61/365,040, converted to US 13/183,287 (Filed July 14, 2011)

2.      Metering Rotary Nanopump, Method of Fabricating Same, and Applications of Same, Seale KT, Wikswo JP, Schaffer DK, Reiserer RS, Darby S, US Patent Application Serial No. 13/183,287 (Filed July 14, 2011)

3.      Photolithographed Micro-Mirror Well for 3D Tomogram Imaging of Individual Cells, Seale K, Reiserer R, Wikswo JP, Rosenthal S, Chamberlain J, Wright C, Markov D, Janetopoulos C, United States Patent, 8,339,704 B2 (December 25, 2012)

4.      Organ on Chip Integration and Applications of the Same, Block III FE, Samson PC, Werner EM, Markov DA, Reiserer RS, McKenzie JR, Cliffel DE, Matloff WJ, Block, Jr. FE, Scherrer JR, Tidwell WH, Wikswo JP, International Patent Application No. PCT/US13/71026 (Filed November 20, 2013)

5.      Peristaltic Micropump and Related Systems and Methods, Gould PA, Hoang LT, Scherrer J, Matloff WJ, Seale KT, Curtis EL, Schaffer DK, Hall DJ, Kole A, Reiserer RS, Tidwell WH, Samson PC, Wikswo JP, National Phase Patent Application Serial No. 13/877,925 (Filed July 16, 2013)

6.      Improved RPPM/RPV Designs and Implementations of Same, Wikswo JP, Block III  FE, Samson PC, Markov DA, Resierer RS, Matloff WJ, Tidwell WH, US Provisional Patent Application Serial No. 61/808,455 (Filed April 4, 2013)

7.      ZebraSpin: A method of orienting zebrafish embryos for treatment and microscopy, Bulow C, Schaffer D, Seale KT, US Provisional Patent Application Serial No. 61/994,366 (Filed May 16, 2014)

8.      Systems And Methods For Serial Treatment Of A Muscular-Skeletal Deformity, Schoenecker J, Braman N, Houston A, Mendive M, Miao S. US Provisional Patent Application Serial No. 62/222,972 (Filed September 24, 2015)

9.      Devices, kits, and methods for monitoring disease states, Kevin Cyr, Christina Marasco, Jennifer Colby. US Patent Application No. PCT/US2017/034059 (Filed May 23, 2017)

10.   Metabolic rate measurement apparatus and method thereof, Christina Marasco, Jonathan Ehrman, Amaury Perez, Orlando Hoilett. US Provisional Patent Application Serial No. 62/745445 (Filed October 14, 2018)

11.   Flexible Plantar Pressure-Sensing Insole for Gait Analysis, Christina Marasco, Jonathan Ehrman, Matthew Gothard. US Provisional Patent Application Serial No. 62/747,496 (Filed October 18, 2018)